2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141510A
    myo-Inositol trispyrophosphate hexa-triethylamine 851086-77-6 ≥98.0%
    myo-Inositol trispyrophosphate (ITPP) hexa-triethylamine is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate hexa-triethylamine is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate hexa-triethylamine enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate hexa-triethylamine can be used in the study of cardiovascular disease and cancer.
    myo-Inositol trispyrophosphate hexa-triethylamine
  • HY-14187S1
    Amiodarone-d5 hydrochloride 98%
    Amiodarone-d5 hydrochloride is deuterated labeled Amiodarone (HY-14187). Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
    Amiodarone-d5 hydrochloride
  • HY-145552A
    Azilsartan mepixetil potassium 2153458-32-1 98%
    Azilsartan mepixetil potassium (QR-01019K) is the antagonist of angiotensin II receptor. Azilsartan mepixetil potassium has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil potassium has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A).
    Azilsartan mepixetil potassium
  • HY-145742S
    1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-d70 sodium 326495-47-0 98%
    1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-d70 (sodium) is deuterium labeled 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is the component of liposomes for drug delivery.
    1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-d70 sodium
  • HY-14656S1
    Diltiazem-(acetoxy-d3) hydrochloride 1217860-13-3 98%
    Diltiazem-(acetoxy-d3) (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].
    Diltiazem-(acetoxy-d3) hydrochloride
  • HY-14664CS
    (3S,5R)-Fluvastatin-d6 sodium 2249799-35-5 ≥98.0%
    (3S,5R)-Fluvastatin-d6 (sodium)?is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive?HMG-CoA reductase?inhibitor with an IC50?of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.
    (3S,5R)-Fluvastatin-d6 sodium
  • HY-14664DS
    (3S,5R)-Fluvastatin-d6 2249799-34-4 98%
    (3S,5R)-Fluvastatin-d6 is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive?HMG-CoA reductase?inhibitor with an IC50?of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.
    (3S,5R)-Fluvastatin-d6
  • HY-147267A
    Evazarsen sodium 2589926-24-7
    Evazarsen sodium is an angiotensinogen synthesis inhibitor and possesses antihypertensive properties.
    Evazarsen sodium
  • HY-147323R
    Ferulic acid 4-O-sulfate (Standard) 86321-29-1
    Ferulic acid 4-O-sulfate (Standard) is the analytical standard of Ferulic acid 4-O-sulfate. This product is intended for research and analytical applications. Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) is a metabolite of Ferulic acid (HY-N0060). Ferulic acid 4-O-sulfate relaxes arteries and lowers blood pressure in mice[1].
    Ferulic acid 4-O-sulfate (Standard)
  • HY-147406A
    Tonlamarsen sodium 2589926-21-4
    Tonlamarsen sodium is a angiotensinogen synthesis reducer, with antihypertensive activity.
    Tonlamarsen sodium
  • HY-14870S3
    Selexipag-d6 1265295-92-8 98%
    Selexipag-d6 is deuterium labeled Selexipag. Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor).
    Selexipag-d6
  • HY-15025AR
    Sildenafil citrate (Standard) 171599-83-0
    Sildenafil (citrate) (Standard) is the analytical standard of Sildenafil (citrate). This product is intended for research and analytical applications. Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.
    Sildenafil citrate (Standard)
  • HY-15025AS
    Sildenafil citrate-d8 1215071-03-6 98%
    Sildenafil (citrate)-d8 is the deuterium labeled Sildenafil citrate. Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.
    Sildenafil citrate-d8
  • HY-150521R
    Hispolon (Standard) 173933-40-9
    4-Hydrazinobenzoic acid (Standard) is the analytical standard of 4-Hydrazinobenzoic acid. This product is intended for research and analytical applications. 4-Hydrazinobenzoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Hispolon (Standard)
  • HY-150617A
    (Rac)-Lartesertib 2020089-41-0 98%
    (Rac)-Lartesertib ((Rac)-M4076) is an isoform of Lartesertib (HY-150617). Lartesertib (M4076) is an inhibitor of the serine/threonine protein kinase ATM with high potency. Lartesertib can inhibit the growth of multiple hematopoietic cell lines. Additionally, when combined with the ATR inhibitor Tuvusertib (HY-111451), Lartesertib can promote the death of tumor cells, activate the immune signaling pathway, and exhibit anti-tumor activity.
    (Rac)-Lartesertib
  • HY-152013S
    L-Palmitoylcarnitine-d3-1 hydrochloride 2692623-98-4 98%
    L-Palmitoylcarnitine-d3-1 (hydrochloride) is deuterium labeled L-Palmitoylcarnitine (chloride). L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.
    L-Palmitoylcarnitine-d3-1 hydrochloride
  • HY-15284S2
    Prasugrel-d4 1189919-49-0 98%
    Prasugrel-d4 is the deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel-d4
  • HY-15284S3
    Prasugrel-13C6 1261394-83-5 98%
    Prasugrel-13C6 is a deuterated labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel-13C6
  • HY-153489A
    ISIS 329993 sodium
    ISIS 329993 sodium is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx sodium has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis
    ISIS 329993 sodium
  • HY-153964A
    PF-06478939 TFA 98%
    PF-06478939 TFA is a non-brain-penetrating peptide that is an agonist at oxytocin (OT) receptor and vasopressin receptor with EC50 values of 0.01 nM and 0.078 nM, respectively.
    PF-06478939 TFA
Cat. No. Product Name / Synonyms Application Reactivity